Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking
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چکیده
منابع مشابه
Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease.
Growing evidence suggests that Huntington's disease (HD), a neurodegenerative movement disorder caused by the mutant huntingtin (htt) with an expanded polyglutamine (polyQ) repeat, is associated with the altered intracellular trafficking and synaptic function. GABA(A) receptors, the key determinant of the strength of synaptic inhibition, have been found to bind to the huntingtin associated prot...
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GABAergic synaptic transmission regulates brain function by establishing the appropriate excitation-inhibition (E/I) balance in neural circuits. The structure and function of GABAergic synapses are sensitive to destabilization by impinging neurotransmitters. However, signaling mechanisms that promote the restorative homeostatic stabilization of GABAergic synapses remain unknown. Here, by quantu...
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Studies in C. elegans have begun to reveal new components and new mechanisms associated with intracellular membrane traffic in a variety of cell types. The worm benefits from many of the advantages of yeast as a genetically tractable organism for these kinds of studies while offering the unique opportunity to probe how these pathways have been extended and modified in the context of a multicell...
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Objective(s): Mutant forms FMS-like tyrosine kinase-3 (FLT3), are reported in 25% of childhood acute lymphoid leukemia (ALL) and 30% of acute myeloid leukemia (AML) patients. In this study, drug response, growth promoting, and protein trafficking of FLT3 wild-type was compared with two active mutants (Internal Tandem Duplication (ITD)) and D835Y. Materials and Methods:FLT3 was expressed on fact...
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Hemes are porphyrins that play a critical role in diverse biological processes. Heme synthesis culminates in the mitochondrial matrix, but the eight-step biosynthetic pathway is spatially shared between the mitochondria and cytoplasm. A recent paper describes the nature of the transporter that translocates the heme precursor coproporphyrinogen III into the mitochondria for heme synthesis. The i...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2019
ISSN: 1662-5102
DOI: 10.3389/fncel.2019.00163